PAT

CANTY imaging systems have been involved in the control to improve yield of fermentation for several years. Measurement of cell size, concentration and viability in real time in batch and perfusion type fermentation is critical to the process yield. The measurement of foam allows operators independent control of anti-foam additions. The measurement of cell size, count, viability and concentration in the lab or at-line is accomplished by our imaging based system which can distinguish a cell form a gas bubbles and other trace particles.

Liquid  analysis using a high resolution CCD/CMOS image sensor that detects turbidity changes in fluids by measuring the transmittance of light. Using advanced software algorithms the system automatically removes gas bubbles from the analysis resulting in highly accurate and repeatable data outputs. This system is designed for inline use with varying pressures, temperatures, and pipe diameters.

The PharmaFlow™ is designed to be installed in-line to monitor WFI so the manufacture can have longer run times and can verify constant compliance with the USP. CANTY can output the particle concentration continuously so that if an upset does occur the operators are aware of it and take samples to the lab for further testing. What’s more, CANTY’s unique vision based system allows for differentiation between particles and gas bubbles. Visual verification is provided and 4-20mA signals or OPC can be used to alarm to an upset condition.