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SINGLE USE PARTICLE ANALYZER

The CANTY SINGLEFLOW™ has been engineered to analyze small volume samples for particle size, shape and concentration in single use systems. The SINGLEFLOW™ easily converts from a lab unit to allow for continuous sampling in-line using sanitary Tri-Clamp™ connections. It offers microscopic, non-destructive viewing and provides particle size analysis with two dimensional results when used in conjunction with the CantyVisionClient™ Software. The vision system, with integral lighting, features precision optics designed to enhance the image prior to display or analysis. The image sensor is a high resolution / high speed CCD camera coupled to a microscopic lens system. The system offers zoom and focus ability, variable lighting, and disposable lens packages. The SINGLEFLOW™ features single use windows as the flush product contact barrier which ensures laminar flow & eliminates pockets for potential product build-up. Sizing down to 0.7 micron is possible with the high magnification optics and high intensity light source. A variety of pharmaceutical process need to be monitored and analyzed real time. This allows engineers and operators to view inside the process and give real-time results with visual verification.

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S.U.EXTERNAL BIOCAM™ Sanitary Process Camera

The single use vessel level system from CANTY allows operators to track the level inside a single use container by way of a camera, allowing for non-contact visual verification of the level. CantyVision™ software can output via 4-20mA or OPC to a PLC or DCS for complete control. The system utilizes the CANTY LED light with fiber optic bundle so the any size bag or container can be accommodated using the same system. The LED light is a cold white light with no heat transfer to the process so zero effect on the process conditions. Multiple control points can be set to alarm at various stages in the process.

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SINGLE USE

CANTY has designed several single use systems. They include level control, foam monitoring, turbidity, and particle size. The applications all use an Ethernet camera for visual verification and can output either 4-20mA or OPC for complete control.

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FERMENTATION

Biopharmaceutical fermentation is a process used in the pharmaceutical industry to produce a wide range of drugs and other therapeutic substances by cultivating microorganisms or cells in a controlled environment. Canty imaging systems significantly enhance fermentation processes by providing detailed, real-time insights into the culture environment by measuring key parameters such as cell size, concentration, and viability directly during fermentation. The systems ensures accurate counts and size distributions down to 0.7 microns (or 0.3 microns with phase contrast), assess cell health, and monitor foam levels.

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LIQUID ANALYSIS / TURBIDITY / CIP

The CANTY liquid analysis units use cameras to detect turbidity, CIP, and other desired process parameters. Liquid analysis using a high resolution CCD/CMOS image sensor that detects turbidity changes in fluids by measuring the transmittance of light. Using advanced software algorithms the system automatically removes gas bubbles from the analysis resulting in highly accurate and repeatable data outputs. This system is designed for inline use with varying pressures, temperatures, and pipe diameters.

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SUB-VISIBLE PARTICLES

Canty PharmaFlow PAT imaging analysis system, measuring down to 0.7 microns. Size, shape and distribution outputs available. Various product handling available including metering pump/syringe injection.

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CHROMATOGRAPHY BEADS
Features:

Bead size

Visual Verification

Differentiate between particles and gas
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WFI – INFLOW™

The Canty Inflow™ is designed to be installed in-line to monitor WFI so the manufacture can have longer run times and can verify constant compliance with the USP. CANTY can output the particle concentration continuously so that if an upset does occur the operators are aware of it and take samples to the lab for further testing. What’s more, CANTY’s unique vision-based system allows for differentiation between particles and gas bubbles. Visual verification is provided and 4-20mA signals or OPC can be used to alarm to an upset condition.

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WFI – WATER FOR INJECTION

In Water for Injection (WFI) or Sterile Water applications, it is vital to measure and quantify the amount of foreign particles such as solids, rouge, droplets, or biofilm in a given volume to ensure the product meets certain purification standards. USP 788 / 1788 is the accepted set of guidelines for testing and concentration limits for particulate matter in injectables.

The CANTY InFlow™ analyzer utilizes dynamic imaging technology that measures the solids, droplets, gas, and any foreign materials, passing through an inline flow cell. Analyzing these particles continuously produces particle count and concentration data which can better inform decisions for downstream purification or upstream process control, as well as ensuring guideline compliance.

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