CANTY imaging systems have been involved in the control to improve yield of fermentation for several years. Measurement of cell size, concentration and viability in real time in batch and perfusion type fermentation is critical to the process yield. The measurement of foam allows operators independent control of anti-foam additions. The measurement of cell size, count, viability and concentration in the lab or at-line is accomplished by our imaging based system which can distinguish a cell form a gas bubbles and other trace particles.
CANTY dynamic image processing performs several valuable functions in fermentation. The system captures images for cells down to .7 micron (.3 micron with phase contrast) and identifies the cell size distribution and culture count for process control. In many cells the cell viability is determined since a count of the ratio of live to dead cells is calculated by way of the cell structure that the image calculates.
